백서에서 불소의 투여가 실험적 치아이동시 파골세포에 의한 골흡수에 미치는 영향
Effects of fluoride on osteoclastic bone resorption during experimentally moved rat molars
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Kim, Do Hoon
Moon, Yoon Shik/Ko, Jea Seung/Kim, Hyun Man
KMID : 0361920000300060723
Abstract
Orthodontic tooth movement requires remodelling of periodontal tissues, especially alveolar bone. Fluoride is known to be a potent inhibitor of osteoclastic bone resorption.
The purpose of this study was to examine the effects of a consumption of fluoride on osteoclast numbers appearing on the pressure side of alveolar bones at experimental tooth movement.
40 male rats were exposed to 0, 10, 25 mg/kg/day of sodium fluoride(NaF) in their drinking water for up to 60 days. Orthodontic appliance were activated to mesially tip maxillary first molar with 50- 70g. The rats were sacrificed at 1, 2, 4 days after initial activation, The number of osteoclast was counted in a 450 X 700 p m2 area interradicular septum on the pressure side of the maxillary first molar.
The results were as follows,
1. There was significantly different osteoclast number between control group and 25 mg/kg/day group at all measured time. (p< 0.05)
2. There was significantly different active bone-resorption area between control group and 25 mg/kg/c´iy group except at 96 hours post activation. (p< 0.05)
3. There was slight reduction of active bone- resorption area in control group from 48 hours to 96 hours but in both 10 mg/kg/day group and 25 mg/kg/day group a slight increase was observed from 48 hours to 96 hours.
키워드
orthodontic movement;fluoride;osteoclast;교정적 치아이동;불소;파골세포
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